Table 1 Animal characteristics at 7 and 21 days postdenervation.
From: Angiotensin II type 1a receptor deficiency alleviates muscle atrophy after denervation
AT1a+/+-Cont (n = 6) | AT1a+/+-Den, 7 days (n = 7) | AT1a+/+-Den, 21 days (n = 7) | AT1a−/−-Cont (n = 5) | AT1a−/−-Den, 7 days (n = 6) | AT1a−/−-Den, 21 days (n = 6) | |
|---|---|---|---|---|---|---|
Body weight (g) pre-operation | 24.6 ± 0.31 | 24.5 ± 0.42 | 24.3 ± 0.39 | 28.0 ± 0.88## | 26.7 ± 0.63 | 25.5 ± 0.97 |
Body weight (g) pre-tissue harvest | 27.8 ± 0.47 | 25.0 ± 0.42** | 26.0 ± 0.46 | 30.1 ± 1.03# | 27.2 ± 0.65**, § | 26.5 ± 0.89** |
Grip strength (N) | 2.49 ± 0.08 | 2.63 ± 0.07 | 2.45 ± 0.08 | 2.75 ± 0.07# | 2.79 ± 0.03 | 2.57 ± 0.09 |
Grip strength (N)/body weight (kg) | 104.39 ± 2.58 | 110.43 ± 3.24 | 103.94 ± 3.37 | 99.48 ± 2.19 | 103.49 ± 1.87 | 99.16 ± 3.22 |
Skeletal muscles (mg) | ||||||
Gastrocnemius | 144.68 ± 2.25 | 89.67 ± 1.10** | 50.82 ± 0.71** | 135.14 ± 2.53# | 93.95 ± 3.86** | 53.18 ± 2.77** |
Tibialis anterior | 52.77 ± 0.57 | 39.23 ± 0.64** | 25.49 ± 0.10** | 55.90 ± 1.39 | 42.12 ± 1.43** | 25.16 ± 1.53** |
Soleus | 8.53 ± 0.43 | 6.78 ± 0.17** | 5.21 ± 0.13** | 8.38 ± 0.41 | 6.78 ± 0.17** | 5.63 ± 0.40** |
Skeletal muscles (mg)/body weight (g) | ||||||
Gastrocnemius | 5.22 ± 0.12 | 3.60 ± 0.10** | 1.96 ± 0.03** | 4.50 ± 0.07## | 3.45 ± 0.08** | 2.00 ± 0.05** |
Tibialis anterior | 1.90 ± 0.03 | 1.57 ± 0.03** | 0.98 ± 0.04** | 1.87 ± 0.06 | 1.55 ± 0.03** | 0.95 ± 0.03** |
Soleus | 0.31 ± 0.02 | 0.25 ± 0.01** | 0.20 ± 0.01** | 0.28 ± 0.01 | 0.25 ± 0.001 | 0.21 ± 0.01** |
