Figure 6
Combination of DNase I with CS/CAZ improved killing efficiency against shedding planktonic and biofilm cells of B. pseudomallei H777. Burkholderia pseudomallei H777 biofilm growth on pegs was untreated or treated with 0.01 U/mL DNase I alone for 24 h followed by addition of CS/CAZ (various concentrations) for another 24 h. The number of shed planktonic cells in the supernatant (a) and of biofilm cells on pegs liberated by sonication (b) were enumerated. The experiment was performed in duplicate in each of three independent experiments. Statistical significance was calculated using one-way ANOVA. Asterisks indicate statistical significance as follows: *p < 0.05 and **p < 0.001.
