Figure 3

Pharmacokinetic evaluation of CrEL NPs by in vivo bioimaging. A near-infrared fluorescent dye ICG was encapsulated in CrEL NPs instead of KS-58 for pharmacokinetic studies. ICG-derived fluorescence was measured with an in vivo imaging system. White dot lines represent region of interest for the quantification of images with statistical analysis (1: Area = 956, Mean = 0, 2: Area = 1937, Mean = 227, 3: Area = 1936, Mean = 226, 4: Area = 1182, Mean = 178, 5: Area = 956, Mean = 136, 6: Area = 1052, Mean = 102, 7: Area = 853, Mean = 0, 8: Area = 855, Mean = 39, 9: Area = 4856, Mean = 5, 10: Area = 451, Mean = 0, and 11: Area = 1205, Mean = 1).