Figure 4
Antitumor efficacy of KS-58 NPs in mice bearing CT26 subcutaneous allografts. (A) Changes in tumor volume and body weight (n = 4 mice per group, expressed as mean ± SD, **p < 0.001 vs. Vehicle control by Dunnett’s test, ††p < 0.001 vs. Control NPs by a Student’s t-test). (B) Immunohistochemical (IHC) staining of tissue sections. Liver, kidney, spleen, and CT26 tumors were collected from the mice were fixed in 10% neutral-buffered formalin, embedded in paraffin, and sectioned. Livers, kidneys, and spleens were stained with hematoxylin and eosin. CT26 tumors were stained with an anti-pERK antibody. Black arrows represent color development regarding to the pEPK expression.
