Table 2 The targets of 41 signaling pathways related to NAFLD.
From: The identification of metabolites from gut microbiota in NAFLD via network pharmacology
KEGG ID and description | Target genes | False discovery rate |
|---|---|---|
hsa04620: Toll-like receptor signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, IL6, CXCL8, TLR4, TLR9, MAPK14 | 5.19E−10 |
hsa04657: IL-17 signaling pathway | MAPK1, RELA, GSK3B, JUN, MAPK8, IL6, PTGS2, CXCL8, MAPK14, CASP3 | 3.26E−13 |
hsa04933: AGE-RAGE signaling pathway in diabetic complications | MAPK1, AKT1, CASP3, RELA, JUN, MAPK8, IL6, CXCL8, MAPK14, NOX1 | 4.70E−13 |
hsa04668: TNF signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, IL6, PTGS2, MAPK14, CASP3 | 3.02E−11 |
hsa04917: Prolactin signaling pathway | AKT1, RELA, GSK3B, MAPK8, MAPK14, MAPK1 | 6.52E−08 |
hsa04660: T cell receptor signaling pathway | MAPK1, AKT1, RELA, JUN, GSK3B, MAPK1, MAPK14, MAPK8 | 5.3E−10 |
hsa04625: C-type lectin receptor signaling pathway | MAPK1, AKT1, RELA, JUN, IL6, PTGS2, MAPK8, IL2, MAPK14 | 1.58E−11 |
hsa04012: ErbB signaling pathway | MAPK1, AKT1, JUN, GSK3B, EGFR, MAPK8 | 0.000000156 |
hsa04664: Fc epsilon RI signaling pathway | MAPK1, AKT1, MAPK14, MAPK8 | 0.0000462 |
hsa04066: HIF-1 signaling pathway | MAPK1, AKT1, RELA, EGFR, IL6, TLR4 | 0.000000552 |
hsa05120: Epithelial cell signaling in Helicobacter pylori infection | RELA, JUN, MAPK8, CXCL8, EFGR, MAPK14, CASP3 | 1.5E−09 |
hsa04722: Neurotrophin signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, MAPK14 | 3.34E−08 |
hsa04662: B cell receptor signaling pathway | MAPK1, AKT1, RELA, JUN, GSK3B | 0.00000319 |
hsa04370: VEGF signaling pathway | MAPK1, AKT1, PTGS2, MAPK14 | 0.0000278 |
hsa04071: Sphingolipid signaling pathway | MAPK1, AKT1, MAPK1, MAPK8, MAPK14, CTSD | 0.000000861 |
hsa04068: FoxO signaling pathway | MAPK1, AKT1, IL6, MAPK8, EGFR, MAPK14 | 0.00000132 |
hsa04919: Thyroid hormone signaling pathway | MAPK1, AKT1, HDAC1, HDAC2, HDAC3, GSK3B | 0.000000974 |
hsa04064: NF-kappa B signaling pathway | RELA, PTGS2, CXCL8, TLR4 | 0.0002 |
hsa04920: Adipocytokine signaling pathway | AKT1, RELA, MAPK8 | 0.0011 |
hsa04062: Chemokine signaling pathway | MAPK1, AKT1, RELA, GSK3B, CXCL8 | 0.00013 |
hsa04630: JAK-STAT signaling pathway | AKT1, IL2, IL6, EGFR | 0.00092 |
hsa04926: Relaxin signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, MAPK14, EGFR | 6.55E−08 |
hsa04622: RIG-I-like receptor signaling pathway | RELA, MAPK8, MAPK14, CXCL8 | 0.0000547 |
hsa04621: NOD-like receptor signaling pathway | RELA, JUN, MAPK8, IL6, CXCL8, TLR4, MAPK14, MAPK1 | 2.15E−08 |
hsa04915: Estrogen signaling pathway | MAPK1, AKT1, JUN, EGFR, CTSD | 0.0000312 |
hsa04024: cAMP signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, HCAR2, ADRB2 | 0.00000112 |
hsa04910: Insulin signaling pathway | MAPK1, AKT1, GSK3B, MAPK8 | 0.000052 |
hsa04072: Phospholipase D signaling pathway | MAPK1, AKT1, EGFR, CXCL8 | 0.00071 |
hsa04150: mTOR signaling pathway | MAPK1, AKT1, GSK3B | 0.0083 |
hsa04912: GnRH signaling pathway | MAPK1, JUN, MAPK8, EGFR, MAPK14 | 0.00000565 |
hsa04151: PI3K-Akt signaling pathway | MAPK1, AKT1, RELA, GSK3B, IL2, EGFR, IL6, TLR4 | 0.00000224 |
hsa04010: MAPK signaling pathway | MAPK1, AKT1, RELA, JUN, MAPK8, EGFR, MAPK14, CASP3 | 0.000000606 |
hsa04921: Oxytocin signaling pathway | MAPK1, JUN, EGFR, PTGS2 | 0.00073 |
hsa04371: Apelin signaling pathway | MAPK1, AKT1, HDAC5 | 0.0059 |
hsa04014: Ras signaling pathway | MAPK1, AKT1, RELA, MAPK8, EGFR | 0.00031 |
hsa04022: cGMP-PKG signaling pathway | MAPK1, AKT1, ADRB2, ADRA2B | 0.00094 |
hsa04261: Adrenergic signaling in cardiomyocytes | MAPK1, AKT1, MAPK14, ADRB2 | 0.00071 |
hsa04015: Rap1 signaling pathway | AKT1, MAPK14, EGFR | 0.0019 |
hsa04550: Signaling pathways regulating pluripotency of stem cells | MAPK1, AKT1, MAPK14, GSK3B | 0.00062 |
hsa04330: Notch signaling pathway | HDAC1, HDAC2 | 0.012 |
hsa04310: Wnt signaling pathway | JUN, MAPK8, GSK3B | 0.0087 |
