Table 1 Optimization of reaction conditions for synthesis of 2-amino-4-(4-chlorophenyl)-6-phenylnicotinonitrile.
Entry | Solvent | Load of catalyst (mg) | Temperature (°C) | Time (min) | Yield (%) |
|---|---|---|---|---|---|
1 | – | – | 100 | 120 | 40 |
2 | – | 10 | 80 | 45 | 70 |
3 | – | 20 | 70 | 28 | 80 |
4 | – | 35 | 70 | 18 | 85 |
5 | – | 50 | 70 | 8 | 95 |
6 | – | 50 | 80 | 7 | 96 |
7 | – | 50 | 60 | 9 | 92 |
8 | EtOH | 50 | Reflux | 80 | 50 |
9 | MeOH | 50 | Reflux | 85 | 50 |
10 | CH3CN | 50 | Reflux | 70 | 65 |
11 | H2O | 50 | Reflux | 80 | 20 |
12 | EtOAc | 50 | Reflux | 85 | 20 |
