Figure 5 | Scientific Reports

Figure 5

From: Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions

Figure 5

Observed eccDNA biogenesis sites and characteristics. (a) Chromosome-scale heatmap of eccDNA sequences observed for the Day 0 samples. Frequency of observed eccDNA is shown in color; low (white) to high (red). Figure made with minimap2 48 and bedtools47. (b) 500 kbp windows with the highest eccDNA mapping frequencies (Top 10 from Day 0 only). (c) Self-alignment of chromosome 9 biogenesis hot spot. Red lines indicate a direct repeat; blue lines indicate an inverted repeat. Plot made using Mummer65.

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