Table 1 Baseline characteristics of population with familial hypercholesterolemia phenotype by sex and the absence–resence of cardiovascular disease.

N (%)

5.088 (42)

7.033 (58)

1.659 (64)

919 (36)

Age, mean (SD)

58 (16)

63 (15)

0.001

67 (11)

73 (11)

0.001

Diabetes mellitus (%)

866 (17)

1.135 (16)

0.37

580 (35)

319 (35)

0.90

Hypertension (%)

2.070 (41)

3.394 (48)

0.001

1.182 (71)

741 (81)

0.001

Current smoker (%)

1.551 (30.5)

1.160 (16.5)

0.001

423 (25)

86 (9)

0.001

BMI, mean (SD)

28 (4)

28 (5)

0.63

29 (4)

30 (5)

0.01

Untreated LDL-C, mmol/l mean (SD)

7.31 (0.98)

7.34 (0.95)

0.22

7.44 (0.90)

7.44 (0.93)

0.96

LDL-C, mmol/L mean (SD) (on LLT)

4.62 (1.5)

4.65 (1.60)

0.14

3.41(1.24)

3.77 (1.29)

0.001

HDL-C, mmol/L mean (SD)

1.31 (0.31)

1.55 (0.36)

0.001

1.24 (0.28)

1.44 (0.33)

0.001

TG, mmol/L mean (SD)

1.72 (0.14)

1.6 (0.71)

0.001

1.65 (0.4)

1.69 (0.73)

0.21

TG/HDL-C (SD)

1.31 (2)

1.03 (1.97)

0.001

1.33(1.42)

1.17 (2.21)

0.002

Basal glucosa mmol/L (SD)

5.8 (1.8)

5.7 (1.8)

0.003

6.4 (2.4)

6.2 (2.3)

0.13

HBA1c, % (SD)

6 (1)

6.1

0.37

6 (1)

6 (1)

0.89

Creatinine mmol/L mean (SD)

0.09 (0.04)

0.05 (0.03)

0.001

0.09 (0.04)

0.08 (0.04)

0.001

SBP mmHg, mean (SD)

131 (14)

129 (16)

0.001

132 (15)

133 (17)

0.03

DBP mmHg, mean (SD)

78 (10)

75 (10)

0.001

74 (10)

74 (10)

0,16

MEDEA (Q1), N (%)

290 (9)

466 (11)

0.05

83 (10)

56 (11)

0.66

MEDEA (Q2), N (%)

485 (15)

708 (16)

0.35

129 (15)

84(16)

0.69

MEDEA (Q3), N (%)

610 (19)

862 (20)

0.61

170 (20)

96 (18)

0.60

MEDEA (Q4), N (%)

592(19)

816 (19)

0.97

150 (18)

92 (18)

0.98

MEDEA (Q5), N (%)

542 (17)

714 (16)

0.46

164 (19)

101 (19)

0.96

Rural population, N (%)

664 (21)

812(18)

0.02

153 (18)

92(18)

0.90