Figure 2
Results of the behavioural-PLS analyses. Panels (b) and (d) show the correlations between the LV brain scores and the GRSs. Error bars are the 95% CIs from the bootstrap procedure. CIs that do not include zero reflect robust correlations between the respective GRS and the brain score in a given condition (i.e., data type) across all participants. Panels (a) and (c) depict the Destrieux ROIs with robust loadings on the LVs in panels (b) and (d), respectively, and visualized with the Freesurfer Surface (https://chrisadamsonmcri.github.io/freesurfer_statsurf_display). In the brain figures in panels (a) and (c), absolute BSR values lower than 3 have been set to zero. Rest BOLDSV = amplitude index of resting state low frequency fluctuations in BOLD signal. SST BOLDM Run 1/2 Up = difference between the GLM-derived run 2 and run 1 betas, based on the Correct Stop > Correct Go contrast. SST BOLDSV Run 1/2 Up = difference between the GLM-derived standard errors associated with the run 2 and run 1 beta, respectively, based on the Correct Stop > Correct Go contrast. SST Run 1/2 BOLDM = average of the GLM-derived run 2 and run 1 betas, based on the Correct Stop > Correct Go contrast. SST Run 1/2 BOLDSV = average of the GLM-derived standard errors associated with the run 2 and run 1 beta, respectively, based on the Correct Stop > Correct Go contrast. LV latent variable, CI confidence interval, LH left hemisphere, RH right hemisphere, AD Alzheimer’s Disease, APOE Apolipoprotein E, MDD Major Depressive Disorder, GRS genetic risk score, SST Stop-Signal Task, GLM general linear model, BOLD blood oxygenation level dependent.
