Table 2 Network statistics and biological process (Gene Ontology) of the interactions.

From: Dopaminergic and cholinergic modulation of the amygdala is altered in female mice with oestrogen receptor β deprivation

Network statistics

Number of nodes

9

  

Number of edges

20

  

Average node degree

4.44

  

Avg. local clustering coefficient

0.767

  

Expected number of edges

1

  

PPI enrichment p-value

 < 1.0 × 10–16

  

Biological process (gene ontology)

Description

Strength

p-value

Negative regulation of behaviour

Any process that stops, prevents, or reduces the frequency, rate

2.4

0.00014***

Behavioural fear response

An acute behavioural change resulting from a perceived external threat

2.08

0.0110*

Social behaviour

Behaviour directed towards society or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group

1.95

0.0171*

Associative learning

Learning by associating a stimulus (the cause) with a particular outcome (the effect)

1.84

0.0017**

Learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time

1.61

0.0000675***

Locomotory behaviour

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions

1.61

0.00059***

Negative regulation of response to external stimulus

Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to an external stimulus

1.31

0.0233*

  1. *(p ≤ 0.05), **(p ≤ 0.01) and ***(p ≤ 0.001) indicates statistically significant.
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