Table 1 Top transcriptional activation (upregulated) and repression (downregulated) responses of iGBS in monocytes.

From: Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host–pathogen interactions and bacterial evasion of phagocytosis

Gene locus tag

Label

Gene product

FC

P-adj

CHF17_RS00245

 

tRNA-Ile

232.25

2.17E − 11

CHF17_RS08755

 

PTS beta-glucoside transporter subunit IIBCA

198.45

0.00E + 00

CHF17_RS03815

 

tetracycline resistance determinant leader peptide

197.68

7.30E − 26

CHF17_RS00445

adhP

Alcohol dehydrogenase AdhP

173.27

0.00E + 00

CHF17_RS01525

lrgB

Antiholin-like protein LrgB

157.58

1.03E − 281

CHF17_RS08465

 

zn-dependent alcohol dehydrogenase family protein

104.75

1.19E − 254

CHF17_RS08750

 

ROK family protein

103.56

0.00E + 00

CHF17_RS01520

 

CidA/LrgA family protein

97.13

5.08E − 75

CHF17_RS02320

 

23S ribosomal RNA

87.20

2.56E − 08

CHF17_RS02745

 

tRNA-Ile

66.90

1.32E − 05

CHF17_RS00240

 

tRNA-Gly

57.83

2.44E − 19

CHF17_RS00440

adhE

Bifunctional acetaldehyde-CoA/alcohol dehydrogenase

57.11

2.35E − 158

CHF17_RS01970

glpK

Glycerol kinase GlpK

56.34

2.18E − 65

CHF17_RS08545

dhaS

Dihydroxyacetone kinase transcriptional activator

51.87

6.33E − 229

CHF17_RS04030

 

ABC-2 family transporter protein

50.06

0.00E + 00

CHF17_RS01980

 

Aquaporin family protein

48.84

1.86E − 208

CHF17_RS01975

glpO

Type 1 glycerol-3-phosphate oxidase

45.01

4.08E − 56

CHF17_RS05665

 

L,D-transpeptidase

44.41

1.67E − 140

CHF17_RS01560

treP

PTS system trehalose-specific EIIBC component

38.09

4.87E − 250

CHF17_RS05275

 

CatB-related O-acetyltransferase

34.53

2.24E − 180

CHF17_RS07525

 

30S ribosomal protein S21

33.65

1.37E − 64

CHF17_RS03425

rplS

50S ribosomal protein L19

32.43

5.52E − 281

CHF17_RS04020

 

HYPOTHETICAL protein

32.07

0.00E + 00

CHF17_RS04025

 

ABC-2 family transporter protein

31.80

6.61E − 186

CHF17_RS10785

 

DUF1304 domain-containing protein

29.84

1.17E − 37

CHF17_RS08890

 

Helix-turn-helix transcriptional regulator

− 15.17

3.80E − 188

CHF17_RS00770

 

Helix-turn-helix transcriptional regulator

− 15.96

2.58E − 191

CHF17_RS01005

 

1,4-beta-N-acetylmuramidase

− 16.26

5.61E − 115

CHF17_RS06625

 

Hypothetical protein

− 16.44

3.74E − 235

CHF17_RS00720

 

Hypothetical protein

− 16.85

6.73E − 158

CHF17_RS00765

 

Hypothetical protein

− 18.75

1.55E − 253

CHF17_RS00760

 

Hypothetical protein

− 20.53

0.00E + 00

CHF17_RS00750

 

Hypothetical protein

− 22.04

8.00E − 237

CHF17_RS00965

 

Phage tail tape measure protein

− 22.09

1.80E − 171

CHF17_RS00745

 

ImmA/IrrE family metallo-endopeptidase

− 25.08

2.11E − 251

CHF17_RS00985

 

DUF1366 domain-containing protein

− 25.25

1.43E − 36

CHF17_RS00980

 

Hypothetical protein

− 26.72

4.26E − 237

CHF17_RS00780

 

ORF6C domain-containing protein

− 27.32

0.00E + 00

CHF17_RS11305

 

Hypothetical protein

− 31.40

6.73E − 284

CHF17_RS00920

 

Phage portal protein

− 41.99

1.29E − 248

CHF17_RS00925

 

Clp protease ClpP

− 42.84

2.80E − 156

CHF17_RS00935

 

Phage head–tail connector protein

− 45.16

1.39E − 107

CHF17_RS00930

 

Phage major capsid protein

− 48.66

0.00E + 00

CHF17_RS00775

 

Hypothetical protein

− 55.68

0.00E + 00

CHF17_RS00960

 

Hypothetical protein

− 58.80

1.16E − 31

CHF17_RS00940

 

Head–tail adaptor protein

− 66.69

2.28E − 69

CHF17_RS00955

 

Hypothetical protein

− 100.50

4.67E − 172

CHF17_RS11320

 

Hypothetical protein

− 129.22

4.41E − 63

CHF17_RS00945

 

HK97 gp10 family phage protein

− 215.30

9.57E − 31

CHF17_RS00950

 

HYPOTHETICAL protein

− 386.98

1.57E − 75

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