Table 2 Optimization conditions of the synthesis of N-cyclohexyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide.

From: Palladium supported magnetic Fucus Vesiculosus extract as a natural and novel catalyst for the synthesis of N-alkyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide derivatives

Entry

Compound

Structure

Isolated yield (%)

1

7a

83

2

7b

77

3

7c

81

4

7d

80

5

7e

75

6

7f

79

7

7g

76

8

7h

82

9

7i

85

10

7j

76

  1. Reaction conditions: Compound 6 (0.3 mmol), potassium carbonate (0.6 mmol), tetrabutylammonium bromide (0.9 mmol), DMF (1 mL) Pd@mFuVe catalyst, 75 °C.
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