Table 1 Demographics of subjects with and without detected levels of peripheral blood Hepatitis C virus (HCV) or HIV RNA.

From: Hepatitis C and HIV detection by blood RNA-sequencing in cohort of smokers

 

HCV detected (n = 228)

HCV not detected (n = 3756)

Statistical tests

Liver disease reported *

77 #

112 ##

p value < 0.0001 hypergeometric test

Liver disease not reported *

151

3644

Age (years)

59.9 ± 5.2

65.6 ± 8.9

p value < 0.0001 t-test

Sex (% Male/n)

67.5% / 154

49.5% / 1858

p value < 0.0001 Fisher's Exact Test

Race (% AA/n)

67.5% / 154

24.4% / 918

p value < 0.0001 Fisher's Exact Test

Current smoking—yes (%/n)

68.9% / 157

33.1% / 1245

p value < 0.0001 Fisher's Exact Test

Comorbidity score ** (range 0–14)

2.40 ± 1.91

2.90 ± 1.97

p value = 0.00013 t-test

 

HIV detected (n = 30)

HIV not detected (n = 3954)

 

HIV infection self-reported *

22 @

83 @@

p value < 0.0001 hypergeometric test

HIV infection not self-reported *

8

3871

Age (years)

57.2 ± 5.1

65.3 ± 8.8

p value < 0.0001 t-test

Sex (% Male/n)

60% / 18

50% / 1994

p value = 0.36 Fisher's Exact Test

Race (% AA/n)

83% / 25

26% / 1047

p value < 0.0001 Fisher's Exact Test

Current smoking—yes (%/n)

70% / 21

35% / 1381

p value < 0.0001 Fisher's Exact Test

Comorbidity score ** (range 0–14)

2.43 ± 1.83

2.88 ± 1.97

p value = 0.2 t-test

  1. # 68 at 5-year follow-up and 9 at 10-year follow-up.
  2. ## 103 at 5-year follow-up and 9 at 10-year follow-up.
  3. @ 15 at 5-year follow-up.
  4. @@ 47 at 5-year follow-up.
  5. *At any visit in the COPDGene study.
  6. **Sum of comorbidities reported, considering Coronary Heart disease, Diabetes, Congestive heart failure, Stroke, Osteoarthritis, Osteoporosis, Hypertension, High cholesterol, Gastroesophageal reflux disease, Stomach ulcers, Obesity, Sleep apnea, Hay fever, Peripheral Vascular Disease30.