Figure 6
Changes in the amniotic fluid proteome are reflected in the maternal circulation and can distinguish term labor. (a) Boxplots showing changes in the amniotic fluid-derived labor signature in the maternal plasma proteomic profiles. The box plots were generated with the R package, ggpubr163. (b) Receiver operating characteristic curves for classifying maternal plasma samples into labor and no labor groups based on the plasma concentrations of proteins identified in the amniotic fluid. The black curve corresponds to the discrimination accuracy of the aggregated proteomic signature of the top 15 amniotic fluid proteins that were most increased in the TIL group compared to the TNL group. The red curve corresponds to the leave-one-out cross-validation (LOOCV)-based predictions of a random forest model trained with 10 proteins selected according to their importance from all amniotic fluid proteins increased in the TIL group compared to the TNL group. The ROC curves were plotted with the R package, pROC164.
