Table 2 Gene-set differential expression of the reduced cellular reprogramming/CR (8 genes), organ dysfunction (12 genes), and mortality (10 genes) signatures in COVID-19 patient cohorts.
From: Predicting severity in COVID-19 disease using sepsis blood gene expression signatures
Cohort | Comparison | Statistical significance (p value) | ||
|---|---|---|---|---|
CR | Organ dysfunction | Mortality | ||
All | Severe (54) vs. moderate (42) | < 0.0001 | < 0.0001 | < 0.0001 |
Severe (54) vs. intermediate (28) | < 0.0001 | 0.0058 | 0.063 | |
Intermediate (28) vs. moderate (42) | < 0.0001 | 0.0021 | 0.0045 | |
Died (20) vs. survived (104) | 0.0014 | 0.0023 | < 0.0001 | |
Early sampled (0–5 days) | Severe (28) vs. moderate (29) | < 0.0001 | 0.00040 | < 0.0001 |
Severe (28) vs. intermediate (19) | 0.053 | 0.47 | 0.037 | |
Intermediate (19) vs. moderate (29) | 0.00020 | 0.0057 | 0.025 | |
Died (11) vs. survived (65) | 0.012 | 0.0095 | 0.00030 | |
Late sampled (6–20 days) | Severe (26) vs. moderate (13) | < 0.0001 | < 0.0001 | 0.0014 |
Severe (26) vs. intermediate (9) | 0.0090 | 0.0020 | 0.44 | |
Intermediate (9) vs. moderate (13) | 0.29 | 0.25 | 0.076 | |
Died (9) vs. survived (39) | 0.043 | 0.13 | 0.0043 | |
