Figure 2 | Scientific Reports

Figure 2

From: Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer

Figure 2

Scatter plot showing mean ± SD CI values at (A) Fa = 0.5 and (B) Fa = 0.75 for treatments of NIRB:DOX at varying relative molar ratios on a panel of four HGSOC cell lines. CI values ≤ 0.9 indicate synergistic effects (green), 0.9 > CI < 1.1 indicate additive effects (yellow), and CI ≥ 1.1 indicate antagonistic effects (red). The 10:1 molar ratio is shown to have consistent synergistic/additive effects in all cell lines at both Fa = 0.5 and Fa = 0.75 except for PEO4, wherein the combination of NIRB and DOX seems to exhibit a wide range of values including those indicative of antagonism across the various molar drug ratios. CI values were calculated using CompuSyn software.

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