Figure 3 | Scientific Reports

Figure 3

From: Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer

Figure 3

(A) Relative FRα expression in the selected panel of OC cell lines with MCF7 (breast cancer cell line) as a negative control and (B) Cellular uptake of folate conjugated versus unconjugated fluorescent calcein loaded liposomes. Flow cytometry was used to confirm the relative expression of FRα in the panel of OC cell lines. Data is presented as mean FITC for treated cells divided by the mean FITC for untreated cells, *p < 0.05 (n = 3). Flow cytometry was used to determine the uptake of folate conjugated and folate unconjugated calcein-loaded liposomes in FRα high (OVCAR8) and low (HEYA8) expressing cells, presented as mean FITC values. Data is presented as mean FITC for treated divided by the mean FITC for untreated cells, *p < 0.05 (n = 3).

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