Figure 6
From: Developmental changes in the extent of drug binding to rat plasma proteins
Plasma protein binding and brain entry of drugs in E19, P4 and non-pregnant female adult rats. Protein-free fraction/whole plasma concentration ratios (%) (black, left y-axis) and brain/plasma ratios (%) (colour, right y-axis) of paracetamol (a), valproate (b), digoxin (c) and lamotrigine (d). Brain entry results obtained from 35 (paracetamol & digoxin), and 37 (valproate & lamotrigine).
