Table 4 Comparison of free fraction of drugs in plasma of humans and rats.

From: Developmental changes in the extent of drug binding to rat plasma proteins

 

Present study (%)

Literature—Rat (%)

Literature—Human (%)

Digoxin

63.2

± 3.7

59.9 65

75.1 65

70 66

Paracetamol

69.4

± 2.5

–

Near 100 67

Olanzapine

59.8

± 9.3

–

< 7 68

Ivacaftor

0.45

± 0.04

–

< 3 64

< 1 63

Valproate

33.5

± 6.4

28 69

10.1 42

20 43

Lamotrigine

69.9

± 5.0

60 70

44 71

  1. Protein-free fraction/whole plasma concentration ratios (%) in plasma of non-pregnant female adult rats in the present study and from literature.
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