Figure 7 | Scientific Reports

Figure 7

From: Cellular senescence affects energy metabolism, immune infiltration and immunotherapeutic response in hepatocellular carcinoma

Figure 7The alternative text for this image may have been generated using AI.

Construction and validation of a prognostic signature based on cellular senescence-related genes. (A) Venn diagram demonstrating the acquisition of 68 differentially expressed cellular senescence-related genes. (B) Results of univariate Cox regression analysis of differentially expressed cellular senescence-associated genes. (C) The coefficients of genes calculated by multivariate Cox regression using LASSO. (D) The partial likelihood deviance of genes. (E) Results of multivariate Cox regression analysis of four differentially expressed cellular senescence-related genes. (F) Kaplan–Meier curves were used to compare the overall survival of HCC patients between the high-risk and low-risk groups. (G) The association of risk scores with survival status and gene expression in HCC patients.(H) ROC curves of the prognostic signature for predicting the risk of death at 1, 3, and 5 years.

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