Figure 7
Gαi/o plays a fundamental role in CXCR4-mediated migration and Gαq/11 is responsible for enhanced cell migration induced by costimulation of CXCR4 and HRH1. Cells were treated with vehicle (A), PTX (100 ng/ml, overnight) (B), or YM254890 (300 nM, 30 min) (C) before the migration assay with 3 nM CXCL12, 100 nM histamine, or both. Data are expressed as mean ± s.e.m. (n = 3). *P < 0.05; ns, not significant.
