Figure 7

Reduction of the CD4⁺ T cell population following ablation of macrophage MHCII expression in the small intestine. (a) Proportion and absolute number of CD4⁺ T cells in the SI or LI of tamoxifen treated CX3CR1^CreER MHCII^fl/fl (Cre +) or MHCII^fl/fl (Cre-) littermate control mice. (b) Proportion of Foxp3⁺ and absolute number of Foxp3⁺ or Foxp3^- CD4⁺ T cells in the SI of tamoxifen treated CX3CR1^CreER MHCII^fl/fl (Cre +) or MHCII^fl/fl (Cre-) littermate control mice. (c) Proportion of Ki67⁺ cells amongst total or Foxp3⁺ and Foxp3^- fractions of CD4⁺ T cells in the SI of tamoxifen treated CX3CR1^CreER MHCII^fl/fl (Cre +) or MHCII^fl/fl (Cre-) control mice. For all panels results are presented as the mean ± SD of data pooled from three independent experiments, with each dot representing an individual mouse (N(Cre-) = 10, N(Cre +) = 9). Statistical comparisons were performed using the Mann–Whitney U test. Asterisks denote statistical significance (***p ≤ 0.001).