Figure 5
From: An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition
Schematics of the mechanism of the ‘flare’ effect. JNJ-605 discontinuation leads to the activation of the AKT/mTOR pathway, which drives (1) PTP1B inactivation by phosphorylation on S50 and S378, and (2) enhances translation of MET kinase. This dual feature leads to hyper-expressed and hyper-activated MET and favours the ‘flare’ effect. Created with BioRender.com.
