Table 2 Model 1 multivariable linear regression*.

From: The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure

Area

Element

Estimate

SE

t value

Pr (> (|t|)

Precipitate

(Intercept)

0.0006

0.0004

1.7

0.08

P

1.0294

0.0481

21.3

< 2 × 10–16

Ca

0.1147

0.0481

4.6

4 × 10–6

Cl

−0.1579

0.0654

−2.4

0.02

Cr

−0.0267

0.0543

−0.5

0.6

Mg

0.0188

0.0269

0.7

0.5

O

1.0471

0.1043

10.0

< 2 × 10–16

Si

−0.8586

0.1119

−7.68

2 × 10–14

Lipid bodies

(Intercept)

−0.0001

0.0002

−0.8

0.4

P

0.4015

0.0352

11.4

< 2 × 10–16

Ca

0.0287

0.0151

1.9

0.06

Cl

−0.0212

0.0343

−0.6

0.5

Cr

0.0068

0.0324

0.2

0.8

Mg

0.0227

0.0194

1.2

0.2

O

0.4233

0.0570

7.4

1.6 × 10–13

Si

−0.2114

0.0310

−6.8

1.2 × 10–11

Mitochondria

(Intercept)

0

0.0002

0.2

0.8

P

0.4713

0.0433

10.9

< 2 × 10–16

Ca

0.0792

0.0214

3.7

0.0002

Cl

0.0491

0.0404

1.2

0.2

Cr

0.0382

0.0394

1.0

0.3

Mg

−0.0118

0.0266

−0.4

0.7

O

0.0998

0.0693

1.4

0.2

Si

0.0369

0.0623

0.1

0.6

Other

(Intercept)

0.0004

0.0001

3.1

0.002

P

0.2499

0.0253

9.9

< 2 × 10–16

Ca

0.0183

0.0121

1.5

0.1

Cl

0.0087

0.0300

0.3

0.8

Cr

0.0163

0.0307

0.5

0.6

Mg

0.0313

0.0223

1.4

0.2

O

0.0940

0.0466

2.0

0.04

Si

0.0122

0.0301

0.4

0.7

  1. *Model 1 was Gd ~ P + Ca + Cl + Cr + Mg + O + Si. Residuals (minimum, median, and maximum) for precipitate, lipid-rich bodies, mitochondria, and other were −0.007, −0.0005, 0.0144; −0.004, −0.0003, 0.0158; −0.004, −0.0001, 0.007; and −0.004, −0.0003, 0.01, respectively. Residual standard of error for electron-dense precipitates was 0.003 on 2265 degrees of freedom, multiple r2 0.29, adjusted r2 0.29, F-statistic 134.1 on 7 and 2265 degrees of freedom, P < 2.2 × 10–16. Residual standard error for lipid-rich bodies was 0.001 on 2475 degrees of freedom, multiple r2 0.09, adjusted r2 0.09, F-statistic 35.8 on 7 and 1036 degrees of freedom, P < 2.2 × 10–16. Mitochondrial residual standard error 0.001 on 1036 degrees of freedom, multiple r2 0.14, adjusted r2 0.14, F-statistic 24.8 on 7 and 1036 degrees of freedom, P < 2.2 × 10–16. For other (presumably intracellular) areas, residual standard of error was 0.001 on 2192 degrees of freedom, multiple r2 0.05, adjusted r2 0.05, F-statistic 16.9 on 7 and 2192 degrees of freedom, P < 2.2 × 10–16. The Akaike information criterion was −13,958 for precipitate, this model.