Table 3 The relationship between antacids and adverse events, treatment discontinuation.

From: Association between pazopanib exposure and safety in Japanese patients with renal cell carcinoma or soft tissue sarcoma

 

No antacids (n = 20)

Antacids (n = 13)

p-value

Treatment discontinuation, n (%)

4 (20.0)

2 (15.4)

1.000

AST Grade 1/2/3/4

8/3/2/0

7/0/1/0

0.692

ALT Grade 1/2/3/4

7/3/2/0

3/0/1/0

0.341

T.Bil Grade 1/2/3/4

4/2/0/0

0/0/0/0

0.091

Nausea Grade 1/2/3/4

2/0/0/0

4/1/2/0

0.013

Vomiting Grade 1/2/3/4

2/0/0/0

2/1/0/0

0.413

Fatigue Grade 1/2/3/4

8/3/0/0

4/2/0/0

0.889

Hand-foot syndrome Grade 1/2/3/4

6/3/0/0

6/2/0/0

0.712

Diarrhea Grade 1/2/3/4

10/1/1/0

5/1/0/0

0.913

Hypertension Grade 1/2/3/4

1/7/5/0

1/7/3/0

0.537

  1. Two-tailed Fisher’s exact test.
  2. AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; T.Bil, Total bilirubin.
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