Table 4 Treatment discontinuation due to adverse events.

From: Association between pazopanib exposure and safety in Japanese patients with renal cell carcinoma or soft tissue sarcoma

 

RCC (n = 14)

STS (n = 19)

p-value

Treatment discontinuation, n (%)

6 (42.8)

0 (0)

0.0027

   Hepatotoxicity, n (%)

5(35.7)

0 (0)

 

       AST Grade 1/2/3/4

1/1/3/0

  

       ALT Grade 1/2/3/4

0/2/3/0

  

       T.Bil Grade 1/2/3/4

1/1/0/0

  

   Nausea or vomiting, n (%)

1 (7.1)

0 (0)

 

       Nausea Grade 1/2/3/4

0/1/0/0

  

       Vomiting Grade 1/2/3/4

1/0/0/0

  
  1. Two-tailed Fisher’s exact test.
  2. RCC, renal cell carcinoma; STS, soft tissue carcinoma.
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