Figure 1
From: Integrated multiomics analysis to infer COVID-19 biological insights
Proteomic and metabolomic analysis of plasma from COVID-19 patients. (A) Holistic view of the experimental design starts with plasma extraction from 57 individuals: 25 healthy individuals and 32 severely diagnosed SARS-CoV-2-positive patients. (B, C) Heat map hierarchical clustering highlights the top 25 significant proteins and metabolites between the two groups, respectively. (D, F) Volcano plot analysis showing DEPs and DEMs, respectively (E, G) Principle component analysis for proteomics and metabolomics profiles, respectively. (H, I) pathway enrichment analysis of untargeted proteomics (H) and metabolomics (I) retrieved from KEGG and Reactome databases using proteins and metabolites passed FDR 5% (q-value) and p value < 0.05. Colours represent different databases. The size of the circle reflects the identified number of hits over the total pathway entities. The x-axis represents the –log10 of the q-value.
