Figure 4

Integrated Knowledge-statistical-omics based network. (A) Integrated knowledge-statistical based network. The black colored nodes represent 14 overlapped features between the knowledge-based and the statistical-based networks interacting with 14 metabolites highlighted in blue and 39 proteins highlighted in red. Unique features highlighted in orange and each up or down regulated feature is marked with an up or down arrow as illustrated in the figure legend. (B, C) Pathway enrichment analyses applied on the knowledge-statistical based network and rerieved from KEGG (red) and Reactome (green) databases. The circle size reflects the number of identified hits in the pathway divided by the total entities within the same pathway. The x-axis represents the –log10 of the q-value.