Figure 6

Representative hematopoietic organ toxicity of rasH2 mice following inhalation exposure to 2-BP (67, 200, or 600 ppm, 6 h/day, 5 days/week, 26 weeks). Typical histology of the bone marrow (A). Spleen weights of males (B,C) and females (D,E). Typical histology of the spleen (F). Summary of the results of various pathological findings of the bone marrow (G) and spleen (H) observed after 2-BP exposure. Dunnett’s multiple comparison test was used to compare the spleen weights with the age-matched control (0 ppm) groups: *p < 0.05.