Table 1 Incidence of the histopathological findings of neoplastic lesions in the all organs.
Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Exposure concentration (ppm) | 0 | 67 | 200 | 600 | Trend test | 0 | 67 | 200 | 600 | Trend test |
No. of animals examined | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | ||
Histopathological findings | ||||||||||
Lung | ||||||||||
Bronchiolo-alveolar adenoma | 3 | 3 | 2 | 5 | 2 | 1 | 5 | 4 | ||
Bronchiolo-alveolar carcinoma | 0 | 1 | 3 | 4 | # | 2 | 2 | 2 | 5 | |
Total tumor | 3 | 4 | 5 | 8 | # | 4 | 3 | 7 | 8 | # |
Skin | ||||||||||
Squamous cell papilloma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | ||
Lymphatic vessel | ||||||||||
Lymphangioma | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | ||
Oral cavity | ||||||||||
Squamous cell carcinoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||
Forestomach | ||||||||||
Squamous cell papilloma | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | ||
Squamous cell carcinoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | ||
Liver | ||||||||||
Hepatocellular adenoma | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | ||
Harderian gland | ||||||||||
Adenoma | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | ||
Urinary bladder | ||||||||||
Urothelial papilloma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||
Lymph node | ||||||||||
Malignant lymphoma | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | # | |
Thymus | ||||||||||
Malignant lymphoma | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 2 | ||
All-sites | ||||||||||
Malignant lymphoma | 0 | 1 | 2 | 1 | 1 | 0 | 0 | 4 | ## | |
Subcutis | ||||||||||
Hemangioma | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | ||
Hemangiosarcoma | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | ||
Total tumor | 0 | 0 | 1 | 2 | # | 0 | 1 | 0 | 0 | |
Spleen | ||||||||||
Hemangiosarcoma | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 0 | ||
Bone marrow | ||||||||||
Hemangioma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||
Nasal cavity | ||||||||||
Hemangiosarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | ||
Vagina | ||||||||||
Hemangiosarcoma | 0 | 0 | 2 | 0 | ||||||
All-sites | ||||||||||
Hemangioma | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | ||
Hemangiosarcoma | 1 | 1 | 3 | 3 | 1 | 3 | 3 | 0 | ||
Total tumor | 1 | 1 | 3 | 4 | 2 | 4 | 3 | 0 | ||