Table 1 Incidence of the histopathological findings of neoplastic lesions in the all organs.

From: Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

 

Male

Female

Exposure concentration (ppm)

0

67

200

600

Trend test

0

67

200

600

Trend test

No. of animals examined

25

25

25

25

25

25

25

25

Histopathological findings

Lung

Bronchiolo-alveolar adenoma

3

3

2

5

 

2

1

5

4

 

Bronchiolo-alveolar carcinoma

0

1

3

4

#

2

2

2

5

 

Total tumor

3

4

5

8

#

4

3

7

8

#

Skin

Squamous cell papilloma

0

0

0

1

 

0

0

0

0

 

Lymphatic vessel

Lymphangioma

0

0

0

1

 

1

0

0

0

 

Oral cavity

Squamous cell carcinoma

0

0

1

0

 

0

0

0

0

 

Forestomach

Squamous cell papilloma

0

0

0

0

 

0

1

1

1

 

Squamous cell carcinoma

0

0

0

1

 

0

0

0

0

 

Liver

Hepatocellular adenoma

0

1

1

0

 

0

0

0

0

 

Harderian gland

Adenoma

0

0

1

0

 

1

0

0

1

 

Urinary bladder

Urothelial papilloma

0

0

0

0

 

1

0

0

0

 

Lymph node

Malignant lymphoma

0

0

2

0

 

0

0

0

2

#

Thymus

Malignant lymphoma

0

1

0

1

 

1

0

0

2

 

All-sites

Malignant lymphoma

0

1

2

1

 

1

0

0

4

##

Subcutis

Hemangioma

0

0

0

1

 

0

1

0

0

 

Hemangiosarcoma

0

0

1

1

 

0

0

0

0

 

Total tumor

0

0

1

2

#

0

1

0

0

 

Spleen

Hemangiosarcoma

1

1

2

2

 

1

3

1

0

 

Bone marrow

Hemangioma

0

0

0

0

 

1

0

0

0

 

Nasal cavity

Hemangiosarcoma

0

0

0

0

 

0

0

1

0

 

Vagina

Hemangiosarcoma

     

0

0

2

0

 

All-sites

Hemangioma

0

0

0

1

 

1

1

0

0

 

Hemangiosarcoma

1

1

3

3

 

1

3

3

0

 

Total tumor

1

1

3

4

 

2

4

3

0

 
  1. #p < 0.05 and ##p < 0.01 by Peto trend test.