Table 4 Tyrosinase inhibitory activities of 10a–m.

From: Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

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Compound

R

IC50(µM) ± RSDa

10a

155.46 ± 4.39

10b

≥ 200 µM

10c

85.26 ± 2.94

10d

100.83 ± 1.27

10e

47.35 ± 0.13

10f

39.85 ± 0.07

10g

25.75 ± 0.19

10h

168.77 ± 3.60

10i

66.28 ± 0.15

10j

≥200 

10k

61.96 ± 2.58

10l

78.54 ± 0.01

10m

53.34 ± 0.23

Kojic acidb

 

34.93 ± 0.06

  1. 50% inhibitory concentration (IC50).
  2. aValues represent means ± RSD of 3 independent experiments.
  3. bKojic acid as the positive control.
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