Table 1 Minimum inhibitory concentration of the tested flavonoids against S. aureus strains with various QRDR mutations.

From: CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus

 

QRDR mutation(s)

MIC (mg/L)

parC

gyrA

CID12261165

Quercetin

Luteolin

Kaempferol

Baicalein

Apigenin

Levofloxacin

FDA 209P

QS-MSSA

–

–

128

64

32

32

32

128

0.125

NCTC 8325

QS-MSSA

–

–

128

32

32

 > 128

64

 > 128

0.125

USA300 FPR

QR-MRSA

S80Y

S84L

4

16

16

8

8

16

4

Mu50

QR-VISA

S80F

S84L

4

16

16

16

16

4

8

VRS1

QR-VRSA

S80F

S84L

4

16

8

8

32

8

16

VRS5

QR-VRSA

S80Y, E84G

S84L, E88K

2

8

8

8

8

8

32

  1. QS quinolone susceptible, QR quinolone resistant, MSSA methicillin-susceptible S. aureus, MRSA methicillin-resistant S. aureus, VISA vancomycin-intermediate S. aureus, VRSA vancomycin-resistant S. aureus. MICs ≤ 4 mg/L are in bold.
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