Table 4 Excess relative risk per Gy of IHD mortality in relation to 10-year lagged cumulative liver absorbed doses from external radiation exposure, adjusted for various non-radiation factors and alpha absorbed dose to the liver (main analysis, residents).

From: Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers

Cutpoint, Gy/year

Model parameters

Both sexes

Males

Females

p valuea

0 (without cutpoint16)

ERR/Gy

0.07 (− 0.02; 0.18)

0.06 (− 0.04; 0.18)

0.14 (− 0.07; 0.45)

> 0.50

0.005

ERRL/Gy

− 4.91 (− 6.78, − 2.72)

− 5.46 (− 7.41, − 3.13)

− 2.33 (− 6.98, 4.01)

0.425

ERRH/Gy

0.06 (− 0.02, 0.16)

0.04 (− 0.04, 0.15)

0.13 (− 0.07, 0.44)

p valueb

< 0.001

< 0.001

0.402

0.010

ERRL/Gy

− 2.85 (− 3.69, − 1.89)

− 3.11 (− 4.01, − 2.06)

− 1.86 (− 3.77, 0.69)

0.457

ERRH/Gy

0.07 (− 0.01, 0.17)

0.06 (− 0.02, 0.17)

0.14 (− 0.07, 0.44)

p valueb

< 0.001

< 0.001

0.112

0.015

ERRL/Gy

− 1.96 (− 2.54, − 1.29)

− 2.14 (− 2.76, − 1.42)

− 1.20 (− 2.60, 0.65)

0.417

ERRH/Gy

0.09 (+ 0.00, 0.19)

0.07 (− 0.01, 0.18)

0.16 (− 0.05, 0.46)

p valueb

< 0.001

< 0.001

0.135

0.020

ERRL/Gy

− 1.35 (− 1.81, − 0.82)

− 1.42 (− 1.91, − 0.84)

− 1.00 (− 2.10, 0.48)

> 0.50

ERRH/Gy

0.11 (0.02, 0.21)

0.10 (+ 0.00, 0.21)

0.16 (− 0.05, 0.47)

p valueb

< 0.001

< 0.001

0.111

0.025

ERRL/Gy

− 0.99 (− 1.38, − 0.54)

− 1.00 (− 1.42, − 0.50)

− 0.92 (− 1.83, 0.32)

> 0.50

ERRH/Gy

0.12 (0.03, 0.23)

0.11 (0.01, 0.23)

0.17 (− 0.05, 0.48)

p valueb

< 0.001

< 0.001

0.079

0.030

ERRL/Gy

− 0.66 (− 1.02, − 0.26)

− 0.69 (− 1.07, − 0.25)

− 0.47 (− 1.36, 0.73)

> 0.50

ERRH/Gy

0.12 (0.03, 0.23)

0.11 (0.01, 0.24)

0.16 (− 0.06, 0.47)

p valueb

< 0.001

0.001

0.268

0.035

ERRL/Gy

− 0.42 (− 0.74, − 0.04)

− 0.40 (− 0.75, 0.02)

− 0.50 (− 1.29, 0.57)

> 0.50

ERRH/Gy

0.12 (0.02, 0.23)

0.11 (+ 0.00, 0.23)

0.17 (− 0.05, 0.48)

p valueb

0.009

0.026

0.196

0.040

ERRL/Gy

− 0.28 (− 0.58, 0.06)

− 0.26 (− 0.58, 0.11)

− 0.37 (− 1.13, 0.66)

> 0.50

ERRH/Gy

0.11 (0.02, 0.23)

0.10 (− 0.01, 0.23)

0.17 (− 0.05, 0.48)

p valueb

0.033

0.072

0.278

0.045

ERRL/Gy

− 0.16 (− 0.43, 0.16)

− 0.15 (− 0.44, 0.19)

− 0.14 (− 0.91, 0.89)

> 0.50

ERRH/Gy

0.11 (0.01, 0.23)

0.09 (− 0.01, 0.23)

0.16 (− 0.06, 0.48)

p valueb

0.12

0.175

> 0.50

0.050

ERRL/Gy

− 0.10 (− 0.36, 0.20)

− 0.09 (− 0.36, 0.23)

− 0.15 (− 0.88, 0.83)

> 0.50

ERRH/Gy

0.10 (+ 0.00, 0.22)

0.09 (− 0.02, 0.22)

0.16 (− 0.06, 0.48)

p valueb

0.209

0.31

0.498

  1. Numbers in bold indicate significant differences. The dataset for the analysis was stratified by sex, attained age, calendar period, smoking status, alcohol consumption, alpha dose.
  2. ERR/Gy excess relative risk per unit gray of gamma-ray dose, IHD ischemic heart disease (ICD-9 codes: 410–414).
  3. aTest for heterogeneity between sexes.
  4. bLikelihood ratio test comparing the models with and without cutpoint.
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