Table 5 Excess relative risk of IHD mortality per Gy in relation to 10-year lagged cumulative liver absorbed doses from external radiation exposure, adjusted for various non-radiation factors and alpha absorbed dose to the liver (sensitivity analysis, residents).

From: Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers

Cutpoint, Gy/year

Model parameters

Both sexes

Males

Females

p valuea

0 (without cutpoint16)

ERR/Gy

0.07 (− 0.02; 0.18)

0.06 (− 0.04; 0.18)

0.14 (− 0.07; 0.45)

> 0.50

0.005

ERRL5/Gy

− 0.03 (− 0.14, 0.11)

− 0.07 (− 0.17, 0.08)

0.12 (− 0.14, 0.51)

0.487

ERRH5/Gy

0.27 (0.07, 0.50)

0.28 (0.07, 0.52)

0.24 (− 0.48, 1.14)

p valueb

0.030

0.017

> 0.50

0.010

ERRL5/Gy

− 0.06 (− 0.16, 0.07)

− 0.09 (− 0.19, 0.04)

0.10 (− 0.15, 0.47)

0.419

ERRH5/Gy

0.36 (0.14, 0.61)

0.36 (0.14, 0.62)

0.33 (− 0.47, 1.36)

p valueb

0.003

0.002

> 0.50

0.015

ERRL5/Gy

− 0.06 (− 0.15, 0.06)

− 0.09 (− 0.18, 0.04)

0.05 (− 0.18, 0.41)

0.482

ERRH5/Gy

0.39 (0.16, 0.62)

0.38 (0.15, 0.64)

0.58 (− 0.31, 1.71)

p valueb

0.002

0.002

0.340

0.020

ERRL5/Gy

− 0.07 (− 0.16, 0.05)

− 0.09 (− 0.18, 0.03)

0.03 (− 0.19, 0.36)

0.444

ERRH5/Gy

0.46 (0.21, 0.75)

0.43 (0.19, 0.72)

0.81 (− 0.17, 2.08)

p valueb

< 0.001

< 0.001

0.181

0.025

ERRL5/Gy

− 0.05 (− 0.14, 0.07)

− 0.07 (− 0.17, 0.06)

0.02 (− 0.20, 0.35)

0.464

ERRH5/Gy

0.45 (0.18, 0.75)

0.42 (0.15, 0.72)

0.91 (− 0.12, 2.25)

p valueb

0.002

0.004

0.142

0.030

ERRL5/Gy

− 0.04 (− 0.13, 0.08)

− 0.06 (− 0.16, 0.07)

0.04 (− 0.18, 0.38)

> 0.50

ERRH5/Gy

0.48 (0.19, 0.81)

0.45 (0.16, 0.79)

0.82 (− 0.25, 2.22)

p valueb

0.003

0.004

0.218

0.035

ERRL5/Gy

− 0.01 (− 0.11, 0.12)

− 0.02 (− 0.13, 0.11)

0.05 (− 0.17, 0.38)

> 0.50

ERRH5/Gy

0.39 (0.09, 0.74)

0.36 (0.06, 0.72)

0.82 (− 0.30, 2.31)

p valueb

0.028

0.040

0.243

0.040

ERRL5/Gy

− 0.01 (− 0.10, 0.11)

− 0.03 (− 0.13, 0.10)

0.08 (− 0.14, 0.42)

> 0.50

ERRH5/Gy

0.45 (0.13, 0.82)

0.43 (0.11, 0.82)

0.61 (− 0.53, 2.13)

p valueb

0.014

0.015

0.437

0.045

ERRL5/Gy

0.01 (− 0.08, 0.13)

− 0.01 (− 0.11, 0.12)

0.09 (− 0.13, 0.43)

> 0.50

ERRH5/Gy

0.37 (0.05, 0.76)

0.36 (0.03, 0.75)

0.56 (− 0.62, 2.12)

p valueb

0.055

0.058

> 0.50

0.050

ERRL5/Gy

0.03 (− 0.07, 0.15)

0.01 (− 0.09, 0.14)

0.08 (− 0.14, 0.41)

> 0.50

ERRH5/Gy

0.32 (− 0.00, 0.72)

0.29 (− 0.04, 0.69)

0.74 (− 0.49, 2.42)

p valueb

0.125

0.161

0.361

  1. Numbers in bold indicate significant differences. The dataset for the analysis was stratified by sex, attained age, calendar period, smoking status, alcohol consumption, and alpha dose.
  2. Assessment of the effect of the uninterrupted high dose rate exposure over 5 years.
  3. ERR/Gy excess relative risk per unit gray of gamma-ray dose, IHD ischemic heart disease (ICD-9 codes: 410–414).
  4. aTest for heterogeneity between sexes.
  5. bLikelihood ratio test comparing the models with and without cutpoint.
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