Table 6 Excess relative risk per Gy of IHD mortality in relation to cumulative liver absorbed doses from external gamma-ray exposure, adjusted for various non-radiation factors and alpha absorbed dose to the liver (sensitivity analyses—various lag periods, both sexes, residents).

From: Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers

Cutpoint, Gy/year

Model parameters

Lag periods

0 years

5 years

20 years

30 years

0 (without cutpoint16)

ERR/Gy

0.09 (− 0.00, 0.19)16

0.08 (− 0.01, 0.18)

0.06 (− 0.03, 0.17)

0.06 (− 0.04, 0.18)

0.005

ERRL/Gy

− 5.72 (− 7.13, − 4.04)

− 5.12 (− 6.78, − 3.18)

− 4.33 (− 7.06, − 1.09)

− 5.20 (− 9.57, 0.13)

ERRH/Gy

0.06 (− 0.02, 0.16)

0.06 (− 0.02, 0.16)

0.05 (− 0.04, 0.15)

0.05 (− 0.04, 0.16)

p valuea

< 0.001

0.152

0.01

0.053

0.010

ERRL/Gy

− 3.18 (− 3.88, − 2.37)

− 2.96 (− 3.72, − 2.08)

− 2.79 (− 3.87, − 1.53)

− 2.89 (− 4.47, − 1.01)

ERRH/Gy

0.09 (0.01, 0.19)

0.08 (+ 0.00, 0.18)

0.06 (− 0.03, 0.16)

0.05 (− 0.04, 0.16)

p valuea

< 0.001

0.05

< 0.001

0.003

0.015

ERRL/Gy

− 2.18 (− 2.68, − 1.60)

− 2.06 (− 2.59, − 1.44)

− 1.83 (− 2.56, − 0.97)

− 2.08 (− 3.05, − 0.92)

ERRH/Gy

0.11 (0.02, 0.21)

0.10 (0.01, 0.19)

0.07 (− 0.02, 0.17)

0.06 (− 0.03, 0.17)

p valuea

< 0.001

0.023

< 0.001

< 0.001

0.020

ERRL/Gy

− 1.52 (− 1.92, − 1.05)

− 1.42 (− 1.85, − 0.93)

− 1.28 (− 1.83, − 0.63)

− 1.44 (− 2.17, − 0.58)

ERRH/Gy

0.13 (0.04, 0.23)

0.11 (0.03, 0.22)

0.08 (− 0.01, 0.19)

0.07 (− 0.03, 0.18)

p valuea

< 0.001

0.009

< 0.001

0.001

0.025

ERRL/Gy

− 1.13 (− 1.47, − 0.73)

− 1.05 (− 1.42, − 0.63)

− 0.88 (− 1.35, − 0.33)

− 1.14 (− 1.72, − 0.45)

ERRH/Gy

0.15 (0.05, 0.26)

0.13 (0.04, 0.24)

0.09 (− 0.00, 0.20)

0.08 (− 0.02, 0.20)

p valuea

< 0.001

0.005

0.001

0.001

0.030

ERRL/Gy

− 0.80 (− 1.12, − 0.44)

− 0.73 (− 1.06, − 0.35)

− 0.57 (− 0.99, − 0.09)

− 0.76 (− 1.27, − 0.15)

ERRH/Gy

0.15 (0.05, 0.27)

0.13 (0.04, 0.24)

0.09 (− 0.00, 0.21)

0.08 (− 0.02, 0.20)

p valuea

< 0.001

0.005

0.01

0.009

0.035

ERRL/Gy

− 0.56 (− 0.85, − 0.23)

− 0.50 (− 0.81, − 0.15)

− 0.33 (− 0.72, 0.11)

− 0.50 (− 0.97, 0.05)

ERRH/Gy

0.15 (0.05, 0.27)

0.13 (0.03, 0.25)

0.09 (− 0.01, 0.20)

0.08 (− 0.02, 0.21)

p valuea

< 0.001

0.007

0.072

0.044

0.040

ERRL/Gy

− 0.41 (− 0.67, − 0.11)

− 0.36 (− 0.63, − 0.04)

− 0.21 (− 0.56, 0.19)

− 0.36 (− 0.78, 0.14)

ERRH/Gy

0.15 (0.05, 0.27)

0.13 (0.03, 0.24)

0.09 (− 0.01, 0.20)

0.08 (− 0.02, 0.21)

p valuea

0.001

0.01

0.153

0.087

0.045

ERRL/Gy

− 0.28 (− 0.52, 0.01)

− 0.23 (− 0.49, 0.06)

− 0.09 (− 0.41, 0.28)

− 0.18 (− 0.58, 0.28)

ERRH/Gy

0.14 (0.04, 0.27)

0.12 (0.02, 0.24)

0.08 (− 0.02, 0.20)

0.08 (− 0.03, 0.20)

p valuea

0.009

0.015

0.377

0.268

0.050

ERRL/Gy

− 0.20 (− 0.43, 0.07)

− 0.16 (− 0.40, 0.12)

− 0.02 (− 0.32, 0.33)

− 0.11 (− 0.48, 0.33)

ERRH/Gy

0.14 (0.03, 0.26)

0.12 (0.02, 0.24)

0.07 (− 0.03, 0.19)

0.07 (− 0.03, 0.20)

p valuea

0.03

0.074

> 0.50

0.405

  1. Numbers in bold indicate significant differences. The dataset for the analysis was stratified by sex, attained age, calendar period, smoking status, alcohol consumption, alpha dose.
  2. ERR/Gy excess relative risk per unit gray of gamma-ray dose, IHD ischemic heart disease (ICD-9 codes: 410–414).
  3. aLikelihood ratio test comparing the models with and without cutpoint.
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