Table 7 Excess relative risk per Gy of IHD mortality in relation to 10-year lagged cumulative liver absorbed gamma-ray doses from external exposure (sensitivity analyses—various parameters of the adjustment for alpha and neutron dose, both sexes, residents).

From: Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers

Cutpoint, Gy/year

Model parameters

Sensitivity analysis type

Exclusion of the adjustment for liver absorbed alpha dose

The alternative adjustment for liver absorbed alpha dosea

Association with the weighted sum of liver absorbed gamma-ray + neutron dose (Gy)b

0 (without cutpoint16)

ERR/Gy

0.06 (− 0.01, 0.15)

0.11 (0.01, 0.22)

0.08 (− 0.01, 0.18)

0.005

ERRL/Gy

− 4.77 (− 6.57, − 2.68)

− 5.30 (− 7.12, − 3.15)

− 4.80 (− 6.69, − 2.58)

ERRH/Gy

0.05 (− 0.02, 0.13)

0.08 (− 0.00, 0.19)

0.06 (− 0.02, 0.16)

p valuec

< 0.001

< 0.001

< 0.001

0.010

ERRL/Gy

− 2.69 (− 3.51, − 1.74)

− 2.92 (− 3.77, − 1.94)

− 2.81 (− 3.65, − 1.85)

ERRH/Gy

0.06 (− 0.01, 0.14)

0.10 (0.01, 0.21)

0.07 (− 0.01, 0.17)

p valuec

< 0.001

< 0.001

< 0.001

0.015

ERRL/Gy

− 1.79 (− 2.38, − 1.13)

− 1.88 (− 2.49, − 1.18)

− 1.96 (− 2.54, − 1.29)

ERRH/Gy

0.07 (+ 0.00, 0.15)

0.11 (0.02, 0.22)

0.09 (+ 0.00, 0.19)

p valuec

< 0.001

< 0.001

< 0.001

0.020

ERRL/Gy

− 1.17 (− 1.64, − 0.64)

− 1.20 (− 1.69, − 0.62)

− 1.33 (− 1.79, − 0.80)

ERRH/Gy

0.08 (0.01, 0.16)

0.13 (0.03, 0.24)

0.10 (0.02, 0.21)

p valuec

< 0.001

< 0.001

< 0.001

0.025

ERRL/Gy

− 0.81 (− 1.21, − 0.36)

− 0.82 (− 1.25, − 0.32)

− 0.96 (− 1.36, − 0.51)

ERRH/Gy

0.08 (0.01, 0.17)

0.14 (0.04, 0.26)

0.11 (0.02, 0.22)

p valuec

< 0.001

< 0.001

< 0.001

0.030

ERRL/Gy

− 0.52 (− 0.87, − 0.11)

− 0.47 (− 0.87, − 0.01)

− 0.68 (− 1.03, − 0.28)

ERRH/Gy

0.08 (0.01, 0.17)

0.14 (0.04, 0.26)

0.12 (0.03, 0.23)

p valuec

0.005

0.013

< 0.001

0.035

ERRL/Gy

− 0.29 (− 0.60, 0.08)

− 0.22 (− 0.59, 0.22)

− 0.44 (− 0.76, − 0.06)

ERRH/Gy

0.08 (+ 0.00, 0.17)

0.13 (0.03, 0.25)

0.12 (0.02, 0.23)

p valuec

0.056

0.123

0.007

0.040

ERRL/Gy

− 0.17 (− 0.45, 0.17)

− 0.08 (− 0.42, 0.32)

− 0.28 (− 0.58, 0.06)

ERRH/Gy

0.08 (+ 0.00, 0.17)

0.12 (0.02, 0.25)

0.11 (0.02, 0.23)

p valuec

0.154

0.324

0.032

0.045

ERRL/Gy

− 0.07 (− 0.34, 0.24)

0.05 (− 0.27, 0.42)

− 0.19 (− 0.46, 0.13)

ERRH/Gy

0.07 (− 0.00, 0.16)

0.11 (0.01, 0.24)

0.11 (0.01, 0.23)

p valuec

0.358

> 0.50

0.082

0.050

ERRL/Gy

− 0.03 (− 0.28, 0.26)

0.10 (− 0.20, 0.45)

− 0.11 (− 0.37, 0.19)

ERRH/Gy

0.07 (− 0.01, 0.16)

0.11 (+ 0.00, 0.23)

0.10 (+ 0.00, 0.23)

p valuec

> 0.50

> 0.50

0.179

  1. Numbers in bold indicate significant differences.
  2. ERR/Gy excess relative risk per unit gray of gamma-ray dose, IHD ischemic heart disease (ICD-9 codes: 410− 414).
  3. aUnmonitored for plutonium alpha activity workers divided into two subgroups: only workers of reactors and the rest of unmonitored workers.
  4. bFor all workers.
  5. cLikelihood ratio test comparing the models with and without cutpoint.
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