Table 8 Excess relative risk per Gy of IHD mortality in relation to 10-year lagged cumulative liver absorbed gamma-ray doses from external exposure (sensitivity analyses—dataset restricted and additional inclusion of the adjustment, both sexes, residents).

From: Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers

Cutpoint, Gy/year

Model parameters

Sensitivity analysis type

Dataset restricted to workers employed longer than one year

Inclusion of the adjustment for period of hire

Inclusion of the adjustment for age at hire

0 (without cutpoint16)

ERR/Gy

0.08 (− 0.01, 0.19)

0.08 (− 0.02, 0.20)

0.12 (0.01, 0.25)

0.005

ERRL/Gy

− 5.08 (− 6.94, − 2.89)

− 4.51 (− 6.49, − 2.17)

− 4.53 (− 6.60, − 2.07)

ERRH/Gy

0.06 (− 0.02, 0.16)

0.06 (− 0.02, 0.17)

0.10 (− 0.00, 0.22)

p valuea

< 0.001

< 0.001

< 0.001

0.010

ERRL/Gy

− 2.95 (− 3.79, − 1.99)

–2.88 (− 3.74, − 1.90)

− 2.85 (− 3.75, − 1.81)

ERRH/Gy

0.07 (− 0.01, 0.17)

0.08 (− 0.01, 0.18)

0.11 (0.01, 0.23)

p valuea

< 0.001

< 0.001

< 0.001

0.015

ERRL/Gy

− 2.03 (− 2.61, − 1.36)

− 2.02 (− 2.60, − 1.34)

− 2.04 (− 2.65, − 1.33)

ERRH/Gy

0.09 (+ 0.00, 0.19)

0.09 (− 0.00, 0.20)

0.12 (0.02, 0.25)

p valuea

< 0.001

< 0.001

< 0.001

0.020

ERRL/Gy

− 1.39 (− 1.85, − 0.85)

− 1.43 (− 1.89, − 0.89)

− 1.48 (− 1.95, − 0.93)

ERRH/Gy

0.11 (0.02, 0.21)

0.11 (0.01, 0.22)

0.15 (0.04, 0.28)

p valuea

< 0.001

< 0.001

< 0.001

0.025

ERRL/Gy

− 1.02 (− 1.41, − 0.57)

− 1.11 (− 1.49, − 0.66)

− 1.13 (− 1.53, − 0.67)

ERRH/Gy

0.12 (0.03, 0.23)

0.12 (0.02, 0.24)

0.16 (0.05, 0.30)

p valuea

< 0.001

< 0.001

< 0.001

0.030

ERRL/Gy

− 0.68 (− 1.04, − 0.27)

− 0.79 (− 1.13, − 0.38)

− 0.83 (− 1.18, − 0.41)

ERRH/Gy

0.12 (0.03, 0.24)

0.13 (0.03, 0.25)

0.17 (0.06, 0.32)

p valuea

< 0.001

< 0.001

< 0.001

0.035

ERRL/Gy

− 0.43 (− 0.76, − 0.05)

− 0.54 (− 0.86, − 0.16)

− 0.60 (− 0.92, − 0.21)

ERRH/Gy

0.12 (0.02, 0.24)

0.13 (0.02, 0.25)

0.18 (0.06, 0.33)

p valuea

0.008

0.002

< 0.001

0.040

ERRL/Gy

− 0.29 (− 0.58, 0.06)

− 0.39 (− 0.68, − 0.05)

− 0.45 (− 0.74, − 0.10)

ERRH/Gy

0.12 (0.02, 0.24)

0.13 (0.02, 0.26)

0.18 (0.06, 0.33)

p valuea

0.031

0.006

0.001

0.045

ERRL/Gy

− 0.16 (− 0.44, 0.16)

− 0.26 (− 0.53, 0.06)

− 0.32 (− 0.60, − 0.00)

ERRH/Gy

0.11 (0.01, 0.23)

0.12 (0.02, 0.25)

0.18 (0.06, 0.34)

p valuea

0.116

0.029

0.006

0.050

ERRL/Gy

− 0.10 (− 0.36, 0.20)

− 0.20 (− 0.46, 0.10)

− 0.26 (− 0.51, 0.05)

ERRH/Gy

0.10 (+ 0.00, 0.23)

0.12 (0.01, 0.25)

0.18 (0.06, 0.34)

p valuea

0.205

0.053

0.012

  1. Numbers in bold indicate significant differences.
  2. ERR/Gy excess relative risk per unit gray of gamma-ray dose, IHD ischemic heart disease (ICD-9 codes: 410–414).
  3. aLikelihood ratio test comparing the models with and without cutpoint.
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