Figure 1

Graphical visualization of the study design. The MS patient group consisted of 102 subjects with MS and the HC group included 24 healthy subjects without any sign of MS. The study consisted of five clinical visits, collected at baseline (m00) and then at three-month intervals following baseline (m03, m06, m09, m12) for pwMS. Each clinical visit included the collection of the following clinical outcomes measures for the MS patient group: SDMT, NHPT, and EDSS.