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Figure 1

From: Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Figure 1

Tan IIA-NP + iNSC treatment reduced inflammation and improved expression of tight junction proteins in jejunal mucosa at 12 weeks post-treatment. At 12 weeks PT, treated pigs showed decreased protein levels of (a) TNF-α, (b) TNFR1, (c) phosphorylation of IkBα relative to the control. (d) Treatment decreased binding activity of NF-kB P65 compared to control although not statistically significant. (e) Treatment significantly increased protein expression of gut tight junction proteins occludin, claudin1, and ZO-1 compared to control. Unpaired t-test N = 6 each group. (f) Protein levels of TNF-α, TNFR1, phosphorylated IkBα, and binding activity of NF-kB P65 were correlated with the expression of gut tight junction proteins occludin, claudin1, and ZO-1. Significant correlations (P value < 0.05) are highlighted in red while trending correlations are represented in orange. The number inside each box represents the r-value, r = Pearson correlation coefficient.

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