Table 1 Correlations between changes in fecal SCFAs levels post-stroke and jejunal inflammation at 12 weeks post-treatment in a pig model of ischemic stroke.

From: Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Post-stroke

12 weeks PT

TNF-α

TNF-α receptor 1

Ikbα phosphorylation

NF-kB P65 binding activity

Total SCFAs

P = 0.032c

N.S

P = 0.041c

N.S

r = − 0.619

r = − 0.595

Acetate

P = 0.031c

N.S

P = 0.031c

P = 0.029c

r = − 0.622

r = − 0.623

r = − 0.628

Butyrate

P = 0.030d

P = 0.031d

N.S

P = 0.014d

r = 0.624

r = 0.622

r = 0.075

Propionate

N.S

N.S

N.S

N.S

Isobutyrate

N.S

N.S

P = 0.031b, 0.011c

N.S

r = − 0.623, − 0.700

Isovalerate

N.S

N.S

P = 0.039b, 0.009c

N.S

r = − 0.600, − 0.716

Valerate

N.S

N.S

P = 0.024b

N.S

r = − 0.644

  1. Time point of fecal SCFAs showing significant correlation: a = Acute 1, b = Acute 2, c = Subacute, d = Chronic. r = Pearson correlation coefficient.
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