Table 2 Correlations between post-stroke changes in fecal SCFAs levels and lesion volume and midline shift changes 12 weeks post-treatment.

From: Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Post-stroke

12 weeks PT

Lesion volume (cm3)

Midline shift (mm)

Total SCFAs

P = 0.027b

P = 0.037b

r = − 0.634

r = − 0.605

Acetate

P = 0.038b

P = 0.037b

r = − 0.602

r = − 0.604

Butyrate

N.S

N.S

Propionate

N.S

N.S

Isobutyrate

P = 0.006b

P = 0.042a, 0.012b

r = − 0.741

r = − 0.593, − 0.694

Isovalerate

P = 0.004b, 0.038c

P = 0.007b

r = − 0.763, − 0.604

r = − 0.730

Valerate

P = 0.020b

P = 0.039a

r = − 0.659

r = − 0.600

  1. Time point of fecal SCFAs showing significant correlation: a = Acute 1, b = Acute 2, c = Subacute, d = Chronic. r = Pearson correlation coefficient.