Table 1 Total counts of antioxidant enzymes identified from genome sequences of 19 metazoan species. CAT includes monofunctional catalases only. PRXs separated by subfamily, AhpC-PRX1 (typical 2-Cys PRX), PRX5 (atypical 2-cys PRXs), PRX6 (1-Cys PRX). GPX includes subfamilies GPX 1- 8, with gene sequences obtained from the six species assessed here, as well as from 13 species obtained previously by37 and those assessed. Large numbers indicate total number of unique sequences identified, including isoforms, splice variants. Superscript numbers indicate number of additional identical protein sequences (exact sequence variants).

From: Antioxidant enzymes that target hydrogen peroxide are conserved across the animal kingdom, from sponges to mammals

Species

Phylum

CAT

AhpC-PRX1

PRX5

PRX6

GPX

Amphimedon queenslandica

Porifera

4

1

1

1

2

Xestospongia bergquistia

Porifera

2

1

2

1

1

Tethya wilhelma

Porifera

6

2

1

2

3

Ephydatia muelleri

Porifera

2

2

22

22

2

Oscarella carmela

Porifera

2

2

1

2

2

Sycon ciliatum

Porifera

2

3

1

1

1

Mnemiopsis leidyi

Ctenophora

–

3

–

1

2

Nematostella vectensis

Cnidaria

1

2

1

1

5

Capitella teleta

Annelida

1

3

3

1

3

Lingula anatina

Brachipoda

1

4

1

2

5

Drosophila melanogaster

Arthropoda

2

3

1

4

2

Caenorhabditis elegans

Nematoda

42

4

–

1

7

Strongylocentrotus purpuratus

Echinodermata

1

2

–

1

4

Acanthaster planci

Echinodermata

1

3

–

1

4

Branchiostoma floridae

Chordata

2

3

2

3

7

Ciona intestinalis

Chordata

1

3

–

2

5

Danio rerio

Chordata

21

4

1

1

8

Xenopus tropicalis

Chordata

4

4

1

1

6

Homo sapiens

Chordata

21

82

2

1

8

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