Figure 3
Behavioral and neurophysiological consequences of rTBI. (A) Fear conditioning freezing rates for baseline, Contextual, p = 0.0001 Student’s t-test, and Cued, p = 0.0018 Student’s t-test fear learning (n = 8–11 per group). (B) Shock sensitivity thresholds to flinch, jump, or vocalize pain (n = 8–11 per group). (C) Input–Output curve of CA3-CA1 fEPSP recordings (Inset: individual traces for each of the stimulus intensities) (n = 5–6 per group). (D) Paired Pulse Ratio (PPR) across inter-stimulus interval (n = 5–6 per group). (E) Assessment of the effect of rTBI on hippocampal plasticity after HFS (n = 5–6 per group). (PTP outlined grey 0–2 min, LTP outlined grey 45–55 min). (F) Summary of PTP and LTP fEPSP slopes, (n = 5–6 per group) p = 0.7662, PTP; p = 0.0017, LTP Student’s t-test. All data are means ± SEM, *p < 0.05, ** < 0.01, *** < 0.001.
