Figure 2

Study design. Period 1 was optional to accommodate the most flexible schedule for patients. Patients could enroll in the study before Period 1 in an outpatient clinic or immediately before or during Period 2. At enrollment, patients were screened for eligibility, provided written informed consent, received the smartwatch, and underwent baseline study assessments. During Period 2, patients were washed out of all concomitant Parkinsonian medications. At the final outpatient clinic visit, patients underwent final assessments and returned the smartwatch. The duration of each period may have varied from the specified durations due to the convenience of having the device dispensed and returned at the study site, the timing of the patient’s scheduled visit, and the length of the hospital stay depending on their individual treatment needs; all available data were included in the analysis regardless of the duration of each period. The VME, comprising seven structured motor tasks, was conducted at scheduled times representing relatively poor symptom control (when medication was wearing off [OFF]) and good symptom control (when medication was working well [ON]). ^aDuring the 5-day inpatient period, patients could undergo an optional 2 days of assessments, which were not included in the study. ADL activities of daily living, MDS-UPDRS Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, VME virtual motor examination.