Figure 3 | Scientific Reports

Figure 3

From: Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs

Figure 3

Platelets increase invasion and decrease caspase activity in PCa cells. (A) Platelet-stimulated PCa cell invasion. Invasion was determined by Matrigel assay. Data presented as the mean ± SEM of n = 4–7 independent determinations at the indicated PCa cell:platelet ratios and analyzed by ANOVA and Dunnett’s post-hoc test. * or #, P < 0.05; significantly different from corresponding control. (B) Platelet-induced PCa cell apoptotic resistance. Apoptotic resistance was determined by caspase 3/7 activity assay. Data presented as the mean ± SEM of n = 4–9 independent determinations at the indicated PCa cell:platelet ratios and analyzed by ANOVA and Dunnett’s post-hoc test. * or #, P < 0.05; significantly different from corresponding control.

Back to article page