Figure 4 | Scientific Reports

Figure 4

From: Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs

Figure 4

Candidate PCa cell-platelet signaling axis partners. (A) Schematic representation of potential signaling axes mediating PCa cell-platelet interactions. (B–E) Bar graphs depict expression of platelet signaling partner and corresponding PCa signaling partner based on Garofano et al.24 and TCGA RNA-Seq data. Disease free (DF) survival plots are depicted for PCa signaling partners based on TCGA data. Signaling axes (platelet component-PCa component) displayed include (B) CD55-ADGRE5 and αIIbβ3-FN1, (C) EFNA4-EPHA receptor, (D) LPA-LPAR receptor, and (E) CCL3L1-CCR receptor. TPM, transcript per million; *, Student’s t-test or logrank test, *P < 0.05.

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