Table 4 Hazard ratio (95% CI) of cause-specific mortality1 according to baseline BMI and waist circumference in men and women (BMI: n = 18,149, WC: n = 18,037).

From: Associations of body size with all-cause and cause-specific mortality in healthy older adults

BMI (kg/m2)

Cancer death

Cardiovascular death

Other death

No. events/No. of pts

Incidence rate per 1000 py

HR2 (95% CI)

No.events/ No. of pts

Incidence rate per 1000 py

HR2 (95% CI)

No.events/No. of pts

Incidence rate per 1000 py

HR2 (95% CI)

Men

 < 21.0

10/153

10.67

1.12 (0.58, 2.16)

10/153

10.67

2.15 (1.08, 4.27)

19/153

20.27

2.34 (1.41, 3.86)

21.0–24.9

94/1646

8.71

Ref

49/1646

4.54

Ref

86/1646

7.97

Ref

25.0–29.9

228/4183

8.21

1.02 (0.80, 1.3)

84/4183

3.03

0.74 (0.52, 1.06)

138/4183

4.97

0.72 (0.55, 0.94)

30.0–34.9

93/1633

8.66

1.14 (0.85, 1.52)

39/1633

3.63

0.97 (0.63, 1.50)

51/1633

4.75

0.76 (0.54, 1.09)

 ≥ 35.0

25/417

9.28

1.20 (0.76, 1.90)

14/417

5.19

1.38 (0.74, 2.57)

9/417

3.34

0.53 (0.26, 1.06)

Women

 < 21.0

26/541

7.09

1.43 (0.92, 2.24)

10/541

2.73

1.15 (0.57, 2.32)

37/541

10.08

1.94 (1.31, 2.88)

21.0–24.9

80/2469

4.73

Ref

36/2469

2.13

Ref

77/2469

4.56

Ref

25.0–29.9

147/3959

5.48

1.21 (0.92, 1.60)

54/3959

2.01

1.01 (0.66, 1.54)

84/3959

3.13

0.73 (0.53, 0.99)

30.0–34.9

71/2153

4.89

1.11 (0.80, 1.53)

32/2153

2.20

1.25 (0.77, 2.03)

46/2153

3.17

0.77 (0.53, 1.11)

 ≥ 35.0

43/995

6.60

1.53 (1.04, 2.26)

18/995

2.76

1.65 (0.92, 2.99)

20/995

3.07

0.79 (0.47, 1.32)

Waist circumference

Men

Q1

87/1668

7.95

1.04 (0.78, 1.4)

48/1668

4.39

1.78 (1.13, 2.82)

86/1668

7.86

1.41 (1.03, 1.94)

Q2

93/1828

7.62

Ref

30/1828

2.46

Ref

68/1828

5.57

Ref

Q3

104/1594

9.9

1.29 (0.97, 1.71)

36/1594

3.43

1.38 (0.85, 2.24)

47/1594

4.47

0.80 (0.55, 1.16)

Q4

78/1400

8.44

1.14 (0.84, 1.54)

39/1400

4.22

1.82 (1.12, 2.93)

50/1400

5.41

1.04 (0.72, 1.50)

Q5

86/1514

8.73

1.17 (0.87, 1.58)

40/1514

4.06

1.76 (1.09, 2.86)

50/1514

5.08

1.01 (0.70, 1.47)

Women

Q1

68/2087

4.77

0.96 (0.68, 1.34)

26/2087

1.82

0.86 (0.51, 1.46)

76/2087

5.33

1.97 (1.33, 2.94)

Q2

68/2027

4.91

Ref

29/2027

2.10

Ref

36/2027

2.60

Ref

Q3

75/2127

5.2

1.07 (0.77, 1.48)

36/2127

2.50

1.18 (0.73, 1.93)

52/2127

3.61

1.38 (0.90, 2.11)

Q4

69/1985

5.19

1.07 (0.76, 1.50)

25/1985

1.88

0.93 (0.54, 1.60)

43/1985

3.23

1.28 (0.82, 2.00)

Q5

82/1807

6.83

1.43 (1.03, 1.99)

30/1807

2.50

1.28 (0.76, 2.16)

51/1807

4.25

1.68 (1.08, 2.59)

  1. Waist Circumference Quintile Range (Mean) values for men: Q1:56–93 (88.13); Q2:94–99 (96.67), Q3:100–104 (101.97), Q4:105–110 (107.31), Q5: 111–153 (118.15); women: Q1: 44–82 (76.15), Q2: 83–89 (86.13), Q3: 90–96 (92.95), Q4: 97–104 (100.2), Q5: 105–180 (112.77).
  2. 1Death related to specific causes including cancer (deaths that were related to primary or metastatic cancer), deaths from ischaemic CVD (any ischemic event [myocardial infarction, other coronary heart disease, sudden cardiac death, or ischemic stroke]), or other causes (deaths that were related to causes that were non-cancer or non-CVD [e.g. sepsis, chronic lung disease, dementia]).
  3. 2HRs adjusted for age, smoking status, aspirin treatment arm, diabetes status (yes, no), level of education (< 12 years, ≥ 12 years), living status (at home alone, with others), alcohol consumption (current alcohol consumption, former/never), and longest amount of time walking outside home without any rest.
  4. BMI, body mass index; CI, confidence interval; HR, hazard ratio; py, person years; Ref., reference.
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