Figure 1 | Scientific Reports

Figure 1

From: The trajectory of osteoblast progenitor cells in patients with type 2 diabetes and the predictive model for their osteogenic differentiation ability

Figure 1

Decline in osteogenic differentiation potential along the progression of type 2 diabetes. (a) The probability of osteogenic differentiation impairment along the duration of being diagnosed as diabetic in participants with T2DM. The rate of osteogenic differentiation decreased 4–7% annually during the first 10 years of diagnosis and then decreased at a slower rate. (b) The expression of osteogenic differentiation markers in participants who showed a preserved osteogenic differentiation ability. Box and whisker plots to show a comparison of the expression of osteoblast-specific genes among five groups of participants, including normoglycemic, prediabetic, diabetic for less than 5 years, diabetic for less than 10 years and diabetic for longer than 10 years. All groups had comparable levels of osteoblast-specific gene expression, including BGALP (p = 0.426), COL1A1 (p = 0.205), and RUNX2/PPARγ ratio (RUNX2/PPAR) (p = 0.173).

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