Table 6 Antimicrobial activity of the examined surfactants in comparison to traditional antibiotics against molds and dermatophyte fungi based on the clear zone diameter (CZDa–c, mm), and minimal lethal concentration (MLC, µg/ml).
Treatment | Clear zone diameter (mm) and minimal lethal concentration (MLC μg/ml−1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
C. albicans | Cryptococcus neoforrmans | Trichosporon cataneum | T. rubrum | T. mantigrophytes | ||||||
CZD* | MLC | CZD* | MLC | CZD* | MLC | CZD* | MLC | CZD* | MLC | |
Amino acids-based surfactants (100 μg/ml) | ||||||||||
1. SND-Asparagine | 36 | 128 | 33 | 128 | 35 | 64 | 36 | 128 | 33 | 128 |
2. SND-Histidine | 57 | 16 | 36 | 16 | 48 | 16 | 54 | 16 | 62 | 16 |
3. SND Tryptophan | 45 | 64 | 36 | 64 | 40 | 64 | 43 | 64 | 35 | 64 |
Conventional antifungal (100 μg/mL) | ||||||||||
Fluconazole | 35 | nd | 37 | nd | 38 | nd | 27 | nd | 35 | nd |
Nystatin | 30 | nd | 33 | nd | 42 | nd | 28 | nd | 40 | nd |
Ciclopirox | 33 | nd | 31 | nd | 38 | nd | 26 | nd | 45 | nd |