Table 2 Seven genes which were involved in both infections of three coronaviruses and two neurodegenerative diseases, and the drug targeted against these genes.

From: Shared molecular signatures between coronavirus infection and neurodegenerative diseases provide targets for broad-spectrum drug development

Gene

Gene full name

Num of drugs

Top 1 drug*

Mol. type of drug

Score#

HSP90AA1

Heat shock protein 90 alpha family class A member 1

3

ARGENTEOSIDE A

–

0.94

ALDH2

Aldehyde dehydrogenase 2 family member

5

PRUNETIN

–

12.73

CAV1

Caveolin 1

2

TESTOSTERONE

Small Molecule

1.77

COMT

Catechol-O-methyltransferase

12

ENTACAPONE

Small Molecule

16.91

MTOR

Mechanistic target of rapamycin kinase

4

RIDAFOROLIMUS

Small Molecule

1.13

IGF2R

Insulin like growth factor 2 receptor

1

MANNOSE 6-PHOSPHATE

–

127.3

HSPA1A

Heat shock protein family A (Hsp70) member 1A

1

CARBAMAZEPINE

Small Molecule

2.71

  1. “-”, no data available.
  2. “*”, the drug with the top interaction score.
  3. “#”, the gene-drug interaction scores provided in the DGIdb database which reflect the confidence and specificity of the gene-drug interactions. The larger, the better. Please see Table S7 for more gene-drug interactions.
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